PU139
Product Specifications
CAS Number
158093-65-3
Target
Histone Acetyltransferase
Applications
Epigenetics
Molecular Formula
C12H7FN2OS
Additionnal Information
PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits anticancer activity.
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