JNJ-28583113
Product Specifications
CAS Number
2765255-93-2
Target
TRP Channel
Applications
Neuronal Signaling
Molecular Formula
C19H21F3N2O2
Additionnal Information
JNJ-28583113 is a potent, brain-penetrant antagonist of TRPM2 with an IC50 of 126 nM that protects cells from oxidative stress-induced death and morphological changes. It also inhibits microglial cytokine release in response to pro-inflammatory stimuli and promotes GSK3α/β phosphorylation.
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