BPO-27 (racemate)
BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.
Product Specifications
CAS Number
1314873-02-3
UNSPSC
12352005
Target
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BPO-27-racemate.html
Concentration
10mM
Purity
98.50
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(OC(C2=CC=C(Br)O2)C3=C(N(C)C4=O)C(C(N4C)=O)=C(C5=CC=CC=C5)N36)C6=C1)O
Molecular Formula
C26H18BrN3O6
Molecular Weight
548.34
References & Citations
[1]Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4 (5) :456-459.|[2]Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R) -BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88 (4) :689-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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