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Exatecan

Product Specifications

CAS Number

171335-80-1

Synonyms

DX-8951

Target

Topoisomerase

Applications

DNA Damage/DNA Repair

Molecular Formula

C24H22FN3O4

Additionnal Information

Exatecan (DX-8951), is a water-soluble derivative of camptothecin. It acts as an inhibitor of DNA topoisomerase I with an IC50 value of 1.906 μM. It demonstrates potent antitumor effects and triggers apoptotic cell death after treatment in human pancreatic cancer cells.

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