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Pitolisant

Product Specifications

CAS Number

362665-56-3

Synonyms

BF2.649, Tiprolisant

Target

Histamine Receptor

Applications

Neuronal Signaling

Additionnal Information

Pitolisant (BF2.649, Tiprolisant) is a potent, selective antagonist of the non-imidazole histamine H3 receptor, with a Ki value of 0.16 nM and an EC50 of 1.5 nM as an inverse agonist. It enhances the activity of histaminergic neurons, promoting vigilance and cognitive function. It is useful in research on wakefulness, memory deficits, and cognitive disorders.

Storage Conditions

2 years -20°C liquid

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