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Niraparib hydrochloride

Product Specifications

CAS Number

1038915-64-8

Synonyms

MK-4827 hydrochloride

Target

PARP

Applications

DNA Damage/DNA Repair

Molecular Formula

C19H20N4O.ClH

Additionnal Information

Niraparib hydrochloride (MK-4827 hydrochloride) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor with IC50s of 3.8 and 2.1 nM against both the PARP-1 and PARP-2 enzymes, respectively.It inhibits the repair of radiation-induced DNA double-strand breaks, activates apoptosis, and exhibits anti-tumor activity.
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