LDHA-IN-3
Product Specifications
CAS Number
227010-33-5
Target
LDH
Applications
Metabolism
Molecular Formula
C13H9F3Se
Additionnal Information
LDHA-IN-3, a selenobenzene derivative, is a potent noncompetitive inhibitor of Lactate Dehydrogenase A (LDHA), with an IC50 of 145.2 nM. It exhibits significant anti-tumor activity, effectively reducing LDHA activity and lactate production under both normoxic and hypoxic conditions. It also induces mitochondria-mediated apoptosis through the generation of reactive oxygen species.
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