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Semustine

Product Specifications

CAS Number

13909-09-6

Target

DNA alkylator

Applications

DNA Damage/DNA Repair

Molecular Formula

C10H18ClN3O2

Additionnal Information

Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC) . It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.
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