Semustine
Product Specifications
CAS Number
13909-09-6
Target
DNA alkylator
Applications
DNA Damage/DNA Repair
Molecular Formula
C10H18ClN3O2
Additionnal Information
Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC) . It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.
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