Flonoltinib
Product Specifications
CAS Number
2387765-27-5
Synonyms
JAK2/FLT3-IN-1
Target
JAK
Applications
Angiogenesis
Molecular Formula
C25H34FN7O
Additionnal Information
Flonoltinib (JAK2/FLT3-IN-1) is a potent and selective dual inhibitor of JAK2 and FLT3, with IC50 of of 0.8, 1.4, and 15 nM against JAK2, JAK2V617F, and FLT3, respectively, in in vitro kinase assays. It also inhibits cell proliferation and induces G2/M cell cycle arrest and apoptosis in Hemophagocytic Lymphohistiocytosis (HLH) patients' CD8+T cells, CTLL2 cells, and RAW 264.7 cells.
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