THZ-P1-2
Product Specifications
CAS Number
2058075-45-7
Target
Autophagy
Applications
Autophagy
Molecular Formula
C31H29N7O2
Additionnal Information
THZ-P1-2 is an inhibitor of PI5P4K, which covalently binds to cysteines on a disordered loop in PI5P4Kα/β/γ. It inhibits PI5P4Kα kinase activity with an IC50 of 190 nM and disrupts autophagy by impairing autophagosome clearance and increasing TFEB nuclear localization.
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