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Osimertinib dimesylate

Product Specifications

CAS Number

2070014-82-1

Synonyms

Mereletinib dimesylate, AZD-9291 dimesylate

Target

EGFR

Applications

Protein Tyrosine Kinase

Molecular Formula

C28H33N7O2.2CH4O3S

Additionnal Information

Osimertinib dimesylate (Mereletinib dimesylate, AZD-9291 dimesylate) is a potent, mutant-selective, irreversible inhibitor of EGFR kinase activity with an IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively. It demonstrates anti-tumor activity in xenograft and transgenic T790M EGFR mutant models, supporting its use in non-small cell lung cancer (NSCLC) research.

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