CVN293
Product Specifications
CAS Number
2815296-08-1
Target
Potassium Channel
Applications
Transmembrane Transporters
Molecular Formula
C14H10FN7O
Additionnal Information
CVN293 is a potent, selective, and brain permeable small-molecule inhibitor of potassium (K+) ion channel KCNK13 with an IC50s of 49 nM and 28 nM for hKCNK13 and mKCNK13, respectively. It also inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia with an IC50 of 24 nM and has potential applications in Alzheimer’s disease research.
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