Avitinib maleate
Product Specifications
CAS Number
1557268-88-8
Synonyms
Abivertinib maleate, AC0010 maleate, AC0010MA
Target
EGFR
Applications
Protein Tyrosine Kinase
Molecular Formula
C26H26FN7O2.C4H4O4
Additionnal Information
Avitinib maleate (Abivertinib maleate, AC0010 maleate, AC0010MA) is a third-generation, irreversible, and orally active selective inhibitor of EGFR. It displays IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M, and wild-type EGFR. Avitinib maleate also acts as an inhibitor of BTK that induces apoptosis of BTK in mantle cell lymphoma.
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