RGB-286638 free base
Product Specifications
CAS Number
784210-88-4
Target
CDK
Applications
Cell Cycle
Smiles
COCCN1CCN (CC1) CC2=CC=C (C=C2) C3=N[NH]C4=C3C (=O) C5=C4C=CC=C5NC (=O) NN6CCOCC6
Molecular Formula
C29H35N7O4
Additionnal Information
RGB-286638 free base is a Cyclin-dependent kinase (CDK) inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
Storage Conditions
3 years -20°C powder
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