SPP-86
Product Specifications
CAS Number
1357349-91-7
Target
PI3K
Applications
PI3K/Akt/mTOR
Smiles
CC (C) [N]1N=C (C#CC2=CC=CC=C2) C3=C (N) N=CN=C13
Molecular Formula
C16H15N5
Additionnal Information
SPP-86, a potent and selective cell permeable inhibitor of rearranged during transfection (RET) tyrosine kinase with an IC50 of 8 nM, inhibits RET-induced phosphatidylinositide 3-kinases (PI3K) /Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
Storage Conditions
3 years -20°C powder
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