MS8709
Product Specifications
CAS Number
3060730-06-2
Synonyms
EX-A11295
Target
G9a/GLP
Applications
Epigenetics
Molecular Formula
C64H95F2N11O7S
Additionnal Information
MS8709 (EX-A11295) is a first-in-class G9a/GLP proteolysis targeting chimera (PROTAC) degrader, that induces G9a/GLP degradation in a concentration, time, and ubiquitin-proteasome system (UPS) -dependent manner, and does not alter the mRNA expression of G9a/GLP over other methyltransferases. It displays superior cell growth inhibition in prostate, leukemia, and lung cancer cells over parent G9a/GLP inhibitors.
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