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MS8709

Product Specifications

CAS Number

3060730-06-2

Synonyms

EX-A11295

Target

G9a/GLP

Applications

Epigenetics

Molecular Formula

C64H95F2N11O7S

Additionnal Information

MS8709 (EX-A11295) is a first-in-class G9a/GLP proteolysis targeting chimera (PROTAC) degrader, that induces G9a/GLP degradation in a concentration, time, and ubiquitin-proteasome system (UPS) -dependent manner, and does not alter the mRNA expression of G9a/GLP over other methyltransferases. It displays superior cell growth inhibition in prostate, leukemia, and lung cancer cells over parent G9a/GLP inhibitors.

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