VVD-214
Product Specifications
CAS Number
3026500-20-6
Synonyms
RO7589831, VVD-133214
Target
Others
Applications
Others
Molecular Formula
C20H21F2N3O4S
Additionnal Information
VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI) .
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