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NVL-655

Product Specifications

CAS Number

2739866-40-9

Synonyms

ALK-IN-27

Target

ALK

Applications

Protein Tyrosine Kinase

Molecular Formula

C23H22ClFN6O

Additionnal Information

NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively.

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