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TNG348

Product Specifications

CAS Number

2839740-79-1

Target

JNK

Applications

MAPK

Molecular Formula

C27H23F6N9O

Additionnal Information

TNG348 is an orally bioavailable allosteric inhibitor targeting the ubiquitin-specific protease USP1. It selectively and potently blocks USP1 activity, preventing deubiquitination of proliferative PCNA and FANCD2, which disrupts DNA repair mechanisms. TNG348 demonstrates inhibitory effects against BRCA1/2-mutated and homologous recombination-deficient (HRD) breast and ovarian cancers .
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