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HRX215

Product Specifications

CAS Number

2369583-33-3

Synonyms

Darizmetinib

Target

P38 MAPK

Applications

MAPK

Molecular Formula

C21H17F2N5O3S

Additionnal Information

HRX215 (Darizmetinib) is a first-in-class, highly potent, selective, and orally active inhibitor of MKK4 with an IC50 of 0.02 μM. It enhances liver regeneration, prevents liver failure following extensive hepatectomy in pigs, and has potential to prevent liver failure after major oncological liver resections or transplantation of small liver grafts in humans.

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