PF-05251749 (CK1-IN-2)
Product Specifications
CAS Number
1383376-92-8
Synonyms
CK1-IN-2
Target
Casein Kinase
Applications
Cell Cycle
Molecular Formula
C17H12FN3O2
Additionnal Information
PF-05251749 (CK1-IN-2, Compound Nr.4) is a potent, selective, brain-penetrant inhibitor of Casein Kinase 1 (CK1) in a concentration-dependent manner, with IC50 values of 33.1 nM for CK1d and 51.6 nM for CK1e. It also functions as an inducer of CYP3A, with the potential to treat circadian rhythm disruptions in Alzheimer's and Parkinson's diseases.
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