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JNT-517

Product Specifications

CAS Number

2837993-05-0

Molecular Formula

C18H22F4N4O3

Additionnal Information

JNT-517 is a selective and orally bioavailable inhibitor of SLC6A19, with an IC50 of 47 nM against human SLC6A19 in the isoleucine transport assay. JNT-517 treatment increases urinary excretion of phenylalanine (Phe) in a mouse model of phenylketonuria (PKU), thereby reducing plasma Phe levels.

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