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THZ1

Product Specifications

CAS Number

1604810-83-4

Target

CDK

Applications

Cell Cycle

Molecular Formula

C31H28ClN7O2

Additionnal Information

THZ1 is a potent and covalent inhibitor of CDK7 with an IC50 of 3.2 nM. It also inhibits the CDK12 and CDK13 and downregulates MYC expression. It exhibits strong anti proliferative effect across a broad range of cancer cell lines including human T-cell acute lymphoblastic leukaemia (T-ALL) cancer.

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