INX-315
Product Specifications
CAS Number
2745060-92-6
Target
CDK
Applications
Cell Cycle
Molecular Formula
C19H21N7O3S
Additionnal Information
INX-315 is an orally active and selective inhibitor of CDK2 that induces cell cycle arrest in the G1 phase. It exhibits an IC50 value of 2.3 nM in intracellular NanoBRET assay, respectively. It displays a 50-fold increased CDK2 selectivity compared to CDK1. INX-315 decreases the phosphorylation of CDK2 substrates and suppresses tumor growth in xenograft mouse models in a dose-dependent manner.
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