Fulzerasib
Product Specifications
CAS Number
2641747-54-6
Synonyms
IBI351, GFH925
Target
Ras
Applications
Apoptosis
Molecular Formula
C32H30ClFN6O4
Additionnal Information
Fulzerasib (IBI351, GFH925) is an irreversible small molecule inhibitor for KRAS G12C mutation blocking KRAS pathway signaling pERK with an IC50 of 37 nM. It demonstrates potent anti-tumor activity in multiple KRAS G12C-mutant tumor models including human pancreatic cancer, human lung adenocarcinoma, colorectal adenocarcinoma, and lung cancer models.
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