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PF-06952229

Product Specifications

CAS Number

1801333-55-0

Synonyms

UNII-1KKS7U3X86

Target

TGF-beta/Smad

Applications

TGF-beta/Smad

Molecular Formula

C23H24ClFN4O3

Additionnal Information

PF-06952229 (UNII-1KKS7U3X86) is a selective, orally available inhibitor of the serine/threonine kinase TGF-β receptor 1 (TGF-β-R1) . It inhibits pSMAD2 in both tumor and immune cells, reducing TGF-β signalling and reversing EMT in vitro. It modulates the tumor immune microenvironment and shows antitumor activity in mouse models.

Storage Conditions

2 years -20°C liquid

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