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Tinlorafenib

Product Specifications

CAS Number

2573781-75-4

Synonyms

PF-07284890; ARRY-461

Target

Raf

Applications

MAPK

Molecular Formula

C19H19ClF2N4O3S

Additionnal Information

Tinlorafenib (PF-07284890, ARRY-461) is a potent, brain-penetrant inhibitor of BRAF targeting V600E/V600K mutations with IC50 values of 4.25 nM and 2.7 nM, respectively. It also effectively inhibits ERK phosphorylation and represents a new class of selective BRAF inhibitors for brain tumors.

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