What is the catalog number for GNE-987?

The catalog number for GNE-987 is C01791-25mg.

What sizes are available for GNE-987?

GNE-987 is available in the following size(s): 25 mg.

GNE-987 is currently made to order / not held in immediate stock. Contact us for lead time.

GNE-987

Product Specifications

CAS Number

2417371-71-0

Target

Epigenetic Reader Domain

Applications

Epigenetics

Molecular Formula

C56H67F2N9O8S2

Additionnal Information

GNE-987 is a BRD4-degradating PROTAC consisting of BRD4B1 and BRD4B2 (BRD4 bromodomains 1 and 2) and the VHL E3-ubiquitin ligase. It exhibits BRD4 degradation activity with DC50 of 0.03 nM for the EOL-1 AML cell line. GNE-987 inhibits cell proliferation and induces apoptosis by promoting the rapid and sustained degradation of BRD4 and inhibiting its downstream targets. It also demonstrates potent antitumor activity in AML cell lines.