Exarafenib
Product Specifications
CAS Number
2639957-39-2
Synonyms
KIN-002787, KIN-2787, RAF/KIN_2787
Target
Raf
Applications
MAPK
Molecular Formula
C26H34F3N5O3
Additionnal Information
Exarafenib (KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A4159-08A-HRP 200 µL
Ataxin 3, CT (Ataxin-3, Machado-Joseph Disease Protein 1, Spinocerebellar Ataxia Type 3 Protein, ATXN3, ATX3, MJD, MJD1, SCA3) (Azide free) (HRP) discontinued
Sign In for Pricing
View Details 
MBS2167656-01 0.1 mL
HRP-Linked Monoclonal Antibody to Protection Of Telomeres 1 Homolog (POT1)
Sign In for Pricing
View Details MBS2167656-02 0.2 mL
HRP-Linked Monoclonal Antibody to Protection Of Telomeres 1 Homolog (POT1)
Sign In for Pricing
View Details MBS2167656-03 0.5 mL
HRP-Linked Monoclonal Antibody to Protection Of Telomeres 1 Homolog (POT1)
Sign In for Pricing
View Details MBS2167656-04 1 mL
HRP-Linked Monoclonal Antibody to Protection Of Telomeres 1 Homolog (POT1)
Sign In for Pricing
View Details MBS2167656-05 5 mL
HRP-Linked Monoclonal Antibody to Protection Of Telomeres 1 Homolog (POT1)
Sign In for Pricing
View Details