Elsubrutinib
Product Specifications
CAS Number
1643570-24-4
Synonyms
ABBV-105
Target
BTK
Applications
Protein Tyrosine Kinase
Molecular Formula
C17H19N3O2
Additionnal Information
Elsubrutinib (ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 0.18 μM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcγR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in models of rheumatoid arthritis and lupus.
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