UNC8153
Product Specifications
CAS Number
2929304-60-7
Target
NSD
Applications
Epigenetics
Molecular Formula
C33H37N5O5
Additionnal Information
UNC8153 is a selective degrader of nuclear receptor-binding SET domain-containing 2 (NSD2) with a binding Kd of 24 nM, effectively reducing NSD2 protein levels and the dimethylate lysine 36 of histone 3 (H3K36me2) chromatin mark. Its simple warhead promotes proteasome-dependent degradation of NSD2 via a novel mechanism.
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