What is the catalog number for GNE-7883?

The catalog number for GNE-7883 is C01738-100mg.

What sizes are available for GNE-7883?

GNE-7883 is available in the following size(s): 100 mg.

Is GNE-7883 in stock?

GNE-7883 is currently made to order / not held in immediate stock. Contact us for lead time.

GNE-7883

Product Specifications

CAS Number

2648450-42-2

Target

YAP

Applications

Hippo

Molecular Formula

C28H29FN6O2

Additionnal Information

GNE-7883 is a potent and allosteric small-molecule inhibitor of pan-TEAD, that allosterically blocks the interactions between YAP/TAZ and all human TEAD paralogs through binding to the TEAD lipid pocket. It effectively reduces chromatin accessibility at TEAD motifs, suppresses cell proliferation in a variety of cell line models and achieves strong antitumor efficacy in vivo. Furthermore, it effectively overcomes KRAS G12C inhibitor resistance.