DB2313
Product Specifications
CAS Number
2170606-74-1
Target
Immunology & Inflammation related
Applications
Immunology & Inflammation
Molecular Formula
C42H41FN8O2
Additionnal Information
DB2313 is a potent inhibitor of the transcription factor PU.1, effectively blocking PU.1-dependent reporter gene transactivation with an IC50 of 5 μM. DB2313 demonstrated significant anti-leukemic activity by inducing apoptosis in acute myeloid leukemia (AML) cells. It also increases survival rates and reduces tumor burden in vivo.
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