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P62-mediated mitophagy inducer

Product Specifications

CAS Number

1809031-84-2

Synonyms

PMI

Target

Mitophagy

Applications

Autophagy

Molecular Formula

C14H9IN4O2

Additionnal Information

P62-mediated mitophagy inducer (PMI) is a P62-mediated activator of mitophagy that functions independently of parkin recruitment or mitochondrial membrane potential (ΔΨm) collapse. It remains effective even in cells lacking a fully functional PINK1/Parkin pathway. PMI stabilizes Nrf2 and enhances p62 expression, thereby activating mitophagy.

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