Paxilline
Product Specifications
CAS Number
57186-25-1
Target
ATPase
Applications
Transmembrane Transporters
Molecular Formula
C27H33NO4
Additionnal Information
Paxilline, an indole alkaloid mycotoxin derived from Penicillium paxilli, potently inhibits the BK channel by exerting its effects through direct channel inhibition. Additionally, Paxilline also functions as an inhibitor of sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM-50 μM, depending on the SERCA isoform. Paxilline also possesses significant anticonvulsant and neuroprotective effects.
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