HS-276
Product Specifications
CAS Number
2767422-72-8
Target
TAK1
Applications
MAPK
Smiles
CCC[N]1C (=NC2=CC=C (CN3CCCCC3) C=C12) NC (=O) C4=CC=CC (=C4) C (N) =O
Additionnal Information
HS-276, a potent and highly selective orally bioavailable transforming growth factor-β activated kinase-1 (TAK1) inhibitor with the Ki and IC50 of 2.5 nM and 2.3 nM respectively, shows significant inhibition of TNF-mediated cytokine profiles, correlating with significant attenuation of arthritic-like symptoms in the collagen-induced arthritis (CIA) mouse model of inflammatory rheumatoid arthritis (RA) .
Storage Conditions
3 years -20°C powder
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