SIRT7 inhibitor 97491
Product Specifications
CAS Number
1807758-81-1
Target
Sirtuin
Applications
DNA Damage/DNA Repair
Smiles
NC1=CC=CC (=C1) NC2=NC=C (O2) C3=CC=C (Cl) C=C3
Molecular Formula
C15H12ClN3O
Additionnal Information
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Storage Conditions
3 years -20°C powder
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