M2912

Product Specifications

CAS Number

1460286-21-8

Synonyms

MSC2504877

Target

PARP

Applications

DNA Damage/DNA Repair

Smiles

CC1=CC=C2[N]1C=C (NC2=O) C3=CC=C (C=C3) C (C) (C) O

Molecular Formula

C17H18N2O2

Additionnal Information

M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.