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JR14a

Product Specifications

CAS Number

2411440-41-8

Target

Complement System

Applications

Immunology & Inflammation

Smiles

CC1=C (SC (=C1) C (C2=CC=C (Cl) C=C2) C3=CC=C (Cl) C=C3) C (=O) NC (CCCNC (N) =N) C (O) =O

Molecular Formula

C25H26Cl2N4O3S

Additionnal Information

JR14a, a selective and potent human Complement C3a receptor antagonist, which is assessed by inhibition of intracellular calcium release (IC50=10 nM) induced in human monocyte-derived macrophages by C3a, inhibition of β-hexosaminidase secretion (IC50=8 nM) from human LAD2 mast cells degranulated by C3a, and selectivity for human C3aR over C5aR.

Storage Conditions

3 years -20°C powder

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