Setmelanotide (RM-493)

CC1NC (=O) C (CSSCC (NC (=O) C (CC2=C[NH]C3=CC=CC=C23) NC (=O) C (CCCN=C (N) N) NC (=O) C (CC4=CC=CC=C4) NC (=O) C (CC5=CN=C[NH]5) NC1=O) C (N) =O) NC (=O) C (CCCN=C (N) N) NC (C) =O

Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM.