LDC195943 (IMT1)
Product Specifications
CAS Number
2304621-31-4
Synonyms
IMT1
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Molecular Formula
C21H21NO4
Additionnal Information
LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT) . IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
Storage Conditions
3 years -20°C powder
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