Indirubin-3′-oxime
Product Specifications
CAS Number
667463-82-3
Synonyms
IDR3O, I3O
Target
GSK-3
Applications
PI3K/Akt/mTOR
Smiles
O\N=C1\C (NC2=CC=CC=C12) =C/3C (=O) NC4=CC=CC=C34
Molecular Formula
C16H11N3O2
Additionnal Information
Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. Indirubin-3′-oxime also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. Indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
Storage Conditions
3 years -20°C powder
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