Purified Human CD63 Antibody[H5C6]

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

CD 63; CD63 antigen (melanoma 1 antigen) ; CD63 antigen melanoma 1 antigen; gp55; LAMP 3; LAMP3; Lysosomal associated membrane protein 3; Lysosome associated membrane glycoprotein 3; Mast cell antigen AD1; Melanoma 1 antigen; Melanoma associated antigen ME491; Melanoma associated antigen MLA1; MGC72893; MLA 1; NGA; Ocular melanoma associated antigen; PTLGP40; Tetraspanin 30; Tspan 30; MLA; LAMP; Tetraspanin; CD antigen CD; Melanoma-associated antigen ME; Lysosomal-associated membrane protein; CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30; CD63 antigen; CD antigen CD63; CD63 molecule; Granulophysin; Lysosomal-associated membrane protein 3; Melanoma-associated antigen ME491; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; LIMP; MLA1; LAMP-3