Purified Anti-Human CD63 Antibody[H5C6], Functional Grade

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. None (Azide-Free, Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.

CD 63; CD63 antigen (melanoma 1 antigen) ; CD63 antigen melanoma 1 antigen; gp55; LAMP 3; LAMP3; Lysosomal associated membrane protein 3; Lysosome associated membrane glycoprotein 3; Mast cell antigen AD1; Melanoma 1 antigen; Melanoma associated antigen ME491; Melanoma associated antigen MLA1; MGC72893; MLA 1; NGA; Ocular melanoma associated antigen; PTLGP40; Tetraspanin 30; Tspan 30; MLA; LAMP; Tetraspanin; CD antigen CD; Melanoma-associated antigen ME; Lysosomal-associated membrane protein; CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30; CD63 antigen; CD antigen CD63; CD63 molecule; Granulophysin; Lysosomal-associated membrane protein 3; Melanoma-associated antigen ME491; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; LIMP; MLA1; LAMP-3

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.