Purified Anti-Mouse CD45.1 Antibody[A20]

CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

B220; CD45; CD45 antigen; CD45R; CD45R0; LCA; L-CA; LY5; protein tyrosine phosphatase; receptor type; Receptor-type tyrosine-protein phosphatase C; T200; Ly-5; Ptprc; c polypeptide; CD 45; GP180; homolog of; Leukocyte common antigen; loc; Lyt-4; OTTHUMP00000033813; OTTHUMP00000033816; OTTHUMP00000033817; OTTHUMP00000038574; Protein tyrosine phosphatase receptor type c polypeptide; protein tyrosine phosphatase; receptor type; C; receptor type C; T200 glycoprotein; T200 leukocyte common antigen