Purified Anti-Human CD196/CCR6 Antibody[G034E3]

CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs) . CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

DCR; DRY; GPR; CKRL; STRL; CKR-L; CMKBR; GPRCY; CC-CKR; C-C CKR; CCR; CCR6; BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22; BN 1; BN1; C C chemokine receptor type 6; C C CKR 6; CC chemokine receptor type 6; C-C chemokine receptor type 6; CC CKR 6; CC R6; CCCKR6; CCR 6; CD 196; CD196 antigen; Chemokine (C C motif) receptor 6; Chemokine (C C) receptor 6; Chemokine (CC motif) receptor 6; Chemokine (CC) receptor 6; Chemokine receptor 6; Chemokine receptor like 3; Chemokine receptor-like 3; CKR 6; CKR L3; CKR6; CMKBR 6; DCR 2; DRY 6; G protein coupled receptor 29; GPR 29; GPR CY4; GPRCY 4; GPR-CY4; G-protein coupled receptor 29; LARC receptor; Seven transmembrane receptor lymphocyte 22; STRL 22