Purified Anti-Human TNF-alpha Antibody[HIXB10]
Selected Variant
AN010310P-01
Size: 25 µg
Product Specifications
Background
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Abbreviation
TNF-alpha
Synonyms
APC1; APC1 protein; DIF、TNF-alpha、TNFA、TNFSF2; Differentiation inducing factor; Macrophage cytotoxic factor; macrophage derived; member 2; Membrane Form; monocyte derived; soluble form; sTNFA; TNF superfamily; Tumor necrosis factor alpha; Tumor Necrosis Factor Ligand Superfamily Member; TNFSF; TNF; DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F; TNF alpha; Cachectin; Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF-a
UniProt
P01375
Reactivity
Human
Immunogen
Recombinant Human TNF-alpha protein
Clonality
Monoclonal
Clone
HIXB10
Conjugation
Unconjugated
Applications
FCM
Field of Research
Cardiovascular Biology; Immunology; Signal Transduction; Cancer; Metabolism; Pyroptosis; Inhibition of Apoptosis; Cytokine and Growth Factors; Death Receptors Signaling Pathway; Insulin Signaling Pathway; Metabolic disorders; NF-kB Signaling Pathway; Pancreatic Cancer Markers; Tumor Biomarkers
Purification Method
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Host or Source
Mouse
Control Catalog Number
E-AB-F09813A
Isotype
Mouse IgG2b, κ
Available Sizes
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