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Purified Anti-Human TNF-alpha Antibody[HIXB10]

Selected Variant

AN010310P-01

Size: 25 µg

Product Specifications

Background

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Abbreviation

TNF-alpha

Synonyms

APC1; APC1 protein; DIF、TNF-alpha、TNFA、TNFSF2; Differentiation inducing factor; Macrophage cytotoxic factor; macrophage derived; member 2; Membrane Form; monocyte derived; soluble form; sTNFA; TNF superfamily; Tumor necrosis factor alpha; Tumor Necrosis Factor Ligand Superfamily Member; TNFSF; TNF; DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F; TNF alpha; Cachectin; Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF-a

UniProt

P01375

Reactivity

Human

Immunogen

Recombinant Human TNF-alpha protein

Clonality

Monoclonal

Clone

HIXB10

Conjugation

Unconjugated

Applications

FCM

Field of Research

Cardiovascular Biology; Immunology; Signal Transduction; Cancer; Metabolism; Pyroptosis; Inhibition of Apoptosis; Cytokine and Growth Factors; Death Receptors Signaling Pathway; Insulin Signaling Pathway; Metabolic disorders; NF-kB Signaling Pathway; Pancreatic Cancer Markers; Tumor Biomarkers

Purification Method

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Host or Source

Mouse

Control Catalog Number

E-AB-F09813A

Isotype

Mouse IgG2b, κ

Available Sizes

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